Inhibition of Amyloid β Protein Fibrillation via Carboxypeptidase Y after Protein Trapping Using Immunoaffinity Membranes

Masaki Saito; Tamotsu Zako; Ryoji Takahashi; Youji Shimazaki

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Chemistry Letters

Article . 2016 . Peer-reviewed

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https://dx.doi.org/10.1246/cl....

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Inhibition of Amyloid β Protein Fibrillation via Carboxypeptidase Y after Protein Trapping Using Immunoaffinity Membranes

descriptionPublicationkeyboard_double_arrow_right Article 05 Nov 2016 English Publisher:Oxford University Press (OUP)Journal:Chemistry Letters, volume 45, pages 1,241-1,243 (issn: 0366-7022, eissn: 1348-0715,

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Authors: Masaki Saito; Tamotsu Zako; Ryoji Takahashi; Youji Shimazaki;

doi: 10.1246/cl.160613

Inhibition of Amyloid β Protein Fibrillation via Carboxypeptidase Y after Protein Trapping Using Immunoaffinity Membranes

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Abstract

In this study, we firstly report inhibition of amyloid β42 (Aβ42) fibrillation, which is related to the progression of Alzheimer’s disease, by digestion using proteases, combined with Aβ42 isolation using an immunoaffinity membrane. Especially, digestion of Aβ42 with carboxypeptidase Y (CPY) is effective for the inhibition of Aβ42 fibrillation, indicating that carboxy-terminal digestion of Aβ42 is efficient for the prevention of its fibrillation. The combinational method of the immunoaffinity membrane with CPY digestion is applicable to suppress Aβ42 fibrillation.

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