Abstract Linear solvation energy relationships for solution of O2 in 27 solvents have been examined. Multiple linear regression equations for mole fraction solubility of O2 are developed based on Hildebrand’s solubility parameter as well as the π*, α, and β solvatochromic parameters describing the solvent polarizability/dipolarity, hydrogen bond acidity and hydrogen bond basicity, respectively. Use of the combination of these parameters enables the medium effect on solution of O2 to be correlated and interpreted in a conceptually simple manner.