PTEN at a glance

descriptionPublicationkeyboard_double_arrow_right Article 15 Oct 2012 English Publisher:The Company of BiologistsJournal:Journal of Cell Science, volume 125, pages 4,687-4,692 (issn: 0021-9533, eissn: 1477-9137,

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Authors: Yuji, Shi; Benjamin E, Paluch; Xinjiang, Wang; Xuejun, Jiang;

doi: 10.1242/jcs.093765

pmid: 23223894

pmc: PMC3517091

PTEN at a glance

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Abstract

Since its discovery in 1997 ([Li and Sun, 1997][1]; [Li et al., 1997][2]; [Steck et al., 1997][3]), the phosphatidylinositol (3,4,5)-trisphosphate [PtdIns(3,4,5) P 3] phosphatase and tensin homolog (PTEN) has been established as one of the most frequently mutated tumor suppressor genes in human

Related Organizations

Memorial Sloan Kettering Cancer Center
United States
Roswell Park Cancer Institute
United States

Keywords

PTEN Phosphohydrolase, Ubiquitination, Acetylation, Mice, Gene Expression Regulation, Mutation, Animals, Humans, Phosphorylation, Oxidation-Reduction, Protein Processing, Post-Translational, Signal Transduction

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