p53 at a glance

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 2010 English Publisher:The Company of BiologistsJournal:Journal of Cell Science, volume 123, pages 2,527-2,532 (issn: 0021-9533, eissn: 1477-9137,

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Authors: Colleen A, Brady; Laura D, Attardi;

doi: 10.1242/jcs.064501

pmid: 20940128

pmc: PMC2912460

p53 at a glance

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Abstract

Since its discovery in 1979, the role of the p53 protein in cancer has been studied intensively ([Levine and Oren, 2009][1]). p53 is a crucial tumor suppressor, long-recognized to suppress cancer through the induction of cell-cycle-arrest or apoptosis programs in response to a plethora of different

Related Organizations

Stanford University
United States

Keywords

Transcriptional Activation, Cytoplasm, Neoplasms, Autophagy, Animals, Humans, Apoptosis, Proto-Oncogene Proteins c-mdm2, Tumor Suppressor Protein p53

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