Growth factors and pattern formation

descriptionPublicationkeyboard_double_arrow_right Article 01 Oct 1981 English Publisher:The Company of BiologistsJournal:Development, volume 65, pages 187-207 (issn: 0950-1991, eissn: 1477-9129,

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Authors: J C, Smith;

doi: 10.1242/dev.65.supplement.187

pmid: 6278044

Growth factors and pattern formation

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Abstract

ABSTRACT Growth and pattern formation occur simultaneously in many epimorphic fields and it has been suggested that specification of positional information is somehow linked to cell division. It is possible, therefore, that boundary regions responsible for the specification of positional information produce cell growth factors. In this paper I review the properties of some known growth factors, describe their effects on the cell cycle and discuss how they might act. In developing a convenient in vitro assay for morphogenetic factors it will be much easier to measure incorporation of [3H]thymidine into responding cells than to estimate changes in positional value.

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Harvard University
United States

Keywords

Male, Platelet-Derived Growth Factor, Epidermal Growth Factor, Cell Cycle, Cell Differentiation, Drug Synergism, Receptors, Cell Surface, DNA, ErbB Receptors, Fibroblast Growth Factors, Somatomedins, Animals, Humans, Nerve Growth Factors, Mitogens, Growth Substances, Peptides, Erythropoietin, Cell Division, Cells, Cultured

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