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The role of O-GlcNAcylation in development

descriptionPublicationkeyboard_double_arrow_right Article 15 Mar 2023 United Kingdom, Denmark English Publisher:The Company of BiologistsJournal:Development, volume 150 (issn: 0950-1991, eissn: 1477-9129, Copyright policy )Funded by:WT | Mechanisms of O-GlcNAc si...
Authors: Czajewski, Ignacy; van Aalten, Daan M. F.;

doi: 10.1242/dev.201370

pmid: 36924340

pmc: PMC10108035

The role of O-GlcNAcylation in development

Abstract

ABSTRACT O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes: O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis.

Countries
United Kingdom, Denmark
Related Organizations
Keywords

Polycomb group proteins, Glycosylation, /dk/atira/pure/subjectarea/asjc/1300/1312, Stem Cells, Cell Differentiation, Stem cells, name=Molecular Biology, N-Acetylglucosaminyltransferases, Primer, name=Developmental Biology, O-GlcNAcylation, Differentiation, 616, /dk/atira/pure/subjectarea/asjc/1300/1309, Protein Processing, Post-Translational, Signal Transduction

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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
16
Top 10%
Average
Top 10%
Green
hybrid
Related to Research communities
UArctic