SUMOylation in development and neurodegeneration
Copyright policy )SUMOylation in development and neurodegeneration
ABSTRACT In essentially all eukaryotes, proteins can be modified by the attachment of small ubiquitin-related modifier (SUMO) proteins to lysine side chains to produce branched proteins. This process of ‘SUMOylation’ plays essential roles in plant and animal development by altering protein function in spatially and temporally controlled ways. In this Primer, we explain the process of SUMOylation and summarize how SUMOylation regulates a number of signal transduction pathways. Next, we discuss multiple roles of SUMOylation in the epigenetic control of transcription. In addition, we evaluate the role of SUMOylation in the etiology of neurodegenerative disorders, focusing on Parkinson's disease and cerebral ischemia. Finally, we discuss the possibility that SUMOylation may stimulate survival and neurogenesis of neuronal stem cells.
- University of California, Los Angeles United States
Neurogenesis, Plant Development, Sumoylation, Neurodegenerative Diseases, Nerve Degeneration, Animals, Humans, Growth and Development, Protein Processing, Post-Translational, Signal Transduction
Neurogenesis, Plant Development, Sumoylation, Neurodegenerative Diseases, Nerve Degeneration, Animals, Humans, Growth and Development, Protein Processing, Post-Translational, Signal Transduction
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