The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling
Copyright policy )The specification of sympathetic neurotransmitter phenotype depends on gp130 cytokine receptor signaling
ABSTRACT Sympathetic ganglia are composed of noradrenergic and cholinergic neurons. The differentiation of cholinergic sympathetic neurons is characterized by the expression of choline acetyltransferase (ChAT) and vasoactive intestinal peptide (VIP), induced in vitro by a subfamily of cytokines, including LIF, CNTF, GPA, OSM and cardiotrophin-1 (CT-1). To interfere with the function of these neuropoietic cytokines in vivo, antisense RNA for gp130, the common signal-transducing receptor subunit for neuropoietic cytokines, was expressed in chick sympathetic neurons, using retroviral vectors. A strong reduction in the number of VIP-expressing cells, but not of cells expressing ChAT or the adrenergic marker tyrosine hydroxylase (TH), was observed. These results reveal a physiological role of neuropoietic cytokines for the control of VIP expression during the development of cholinergic sympathetic neurons.
- Max Planck Society Germany
- Max Planck Institute for Brain Research Germany
Neurons, Ganglia, Sympathetic, Membrane Glycoproteins, Molecular Sequence Data, Gene Expression Regulation, Developmental, Chick Embryo, Recombinant Proteins, Choline O-Acetyltransferase, Phenotype, Retroviridae, Gene Expression Regulation, Antigens, CD, Cytokine Receptor gp130, Animals, Cytokines, Humans, RNA, Antisense, Amino Acid Sequence, Receptors, Cytokine, Cells, Cultured
Neurons, Ganglia, Sympathetic, Membrane Glycoproteins, Molecular Sequence Data, Gene Expression Regulation, Developmental, Chick Embryo, Recombinant Proteins, Choline O-Acetyltransferase, Phenotype, Retroviridae, Gene Expression Regulation, Antigens, CD, Cytokine Receptor gp130, Animals, Cytokines, Humans, RNA, Antisense, Amino Acid Sequence, Receptors, Cytokine, Cells, Cultured
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