The sidekick gene, a member of the immunoglobulin superfamily, is required for pattern formation in the Drosophila eye
Copyright policy )The sidekick gene, a member of the immunoglobulin superfamily, is required for pattern formation in the Drosophila eye
ABSTRACT In the Drosophila eye imaginal disc the photoreceptor cells (R cells) differentiate according to a precise spatial and temporal order. The sidekick (sdk) gene is necessary to prevent extra R cells from differentiating during eye disc development. The extra cell appears between R3 and R4 early in R cell clusters and is most likely the result of the mystery cell inappropriately differentiating as an R cell. Mosaic analysis shows that sdk is required neither in the R cells nor in the extra cell, suggesting that sdk is necessary in the surrounding undifferentiated cells. The sdk gene codes for a protein that is a member of the immunoglobu-lin superfamily, having six immunoglobulin domains, thirteen fibronectin repeats and a transmembrane domain. The protein structure is consistent with its participation in cell-cell interaction during eye development.
- Albert Einstein College of Medicine United States
Male, DNA, Complementary, Base Sequence, Molecular Sequence Data, Immunoglobulins, Membrane Proteins, Genes, Insect, Eye, Phenotype, Mutation, Microscopy, Electron, Scanning, Animals, Drosophila Proteins, Insect Proteins, Drosophila, Female, Amino Acid Sequence, Eye Abnormalities, Eye Proteins, Neural Cell Adhesion Molecules
Male, DNA, Complementary, Base Sequence, Molecular Sequence Data, Immunoglobulins, Membrane Proteins, Genes, Insect, Eye, Phenotype, Mutation, Microscopy, Electron, Scanning, Animals, Drosophila Proteins, Insect Proteins, Drosophila, Female, Amino Acid Sequence, Eye Abnormalities, Eye Proteins, Neural Cell Adhesion Molecules
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