Human pancreas development
Copyright policy )Human pancreas development
A wealth of data and comprehensive reviews exist on pancreas development in mammals, primarily mice, and other vertebrates. By contrast, human pancreatic development has been less comprehensively reviewed. Here, we draw together those studies conducted directly in human embryonic and fetal tissue to provide an overview of what is known about human pancreatic development. We discuss the relevance of this work to manufacturing insulin-secreting β-cells from pluripotent stem cells and to different aspects of diabetes, especially permanent neonatal diabetes, and its underlying causes.
- University of Salford United Kingdom
- CENTRAL MANCHESTER UNIVERSITY HOSPITALS NHS FOUNDATION TRUST United Kingdom
- Manchester Academic Health Science Centre United Kingdom
Pluripotent Stem Cells, Species Specificity, Insulin-Secreting Cells, Morphogenesis, Gene Expression Regulation, Developmental, Humans, Cell Differentiation, Pancreas
Pluripotent Stem Cells, Species Specificity, Insulin-Secreting Cells, Morphogenesis, Gene Expression Regulation, Developmental, Humans, Cell Differentiation, Pancreas
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