VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain
Copyright policy )VEGF189 binds NRP1 and is sufficient for VEGF/NRP1-dependent neuronal patterning in the developing brain
The vascular endothelial growth factor (VEGFA, VEGF) regulates neurovascular patterning. Alternative splicing of the Vegfa gene gives rise to three major isoforms termed VEGF121, VEGF165 and VEGF189. VEGF165 binds the transmembrane protein neuropilin 1 (NRP1) and promotes the migration, survival and axon guidance of subsets of neurons, whereas VEGF121 cannot activate NRP1-dependent neuronal responses. By contrast, the role of VEGF189 in NRP1-mediated signalling pathways has not yet been examined. Here, we have combined expression studies and in situ ligand-binding assays with the analysis of genetically altered mice and in vitro models to demonstrate that VEGF189 can bind NRP1 and promote NRP1-dependent neuronal responses.
- University of milan Italy
- University of Milan Italy
- UCL Institute of Ophthalmology United Kingdom
- University of Aberdeen United Kingdom
- UNIVERSITY COLLEGE LONDON, Bartlett School of Planning United Kingdom
Research Report, Vascular Endothelial Growth Factor A, 570, Mouse, Supplementary Data, Models, Neurological, Oligonucleotides, VEGF189, vascular endothelial growth factor (VEGF), BB/J00930X/1, Mice, 092839/Z/10/Z, Models, Animals, Wellcome Trust, mouse, In Situ Hybridization, Neurons, Reverse Transcriptase Polymerase Chain Reaction, Vascular endothelial growth factor (VEGF), Brain, DNA, Sequence Analysis, DNA, Neuron, neuron, Neuropilin-1, Neurological, Biotechnology and Biological Sciences Research Council (BBSRC), RC0321, Neuropilin, neuropilin, RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry, Sequence Analysis
Research Report, Vascular Endothelial Growth Factor A, 570, Mouse, Supplementary Data, Models, Neurological, Oligonucleotides, VEGF189, vascular endothelial growth factor (VEGF), BB/J00930X/1, Mice, 092839/Z/10/Z, Models, Animals, Wellcome Trust, mouse, In Situ Hybridization, Neurons, Reverse Transcriptase Polymerase Chain Reaction, Vascular endothelial growth factor (VEGF), Brain, DNA, Sequence Analysis, DNA, Neuron, neuron, Neuropilin-1, Neurological, Biotechnology and Biological Sciences Research Council (BBSRC), RC0321, Neuropilin, neuropilin, RC0321 Neuroscience. Biological psychiatry. Neuropsychiatry, Sequence Analysis
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