Monitoring Schizosaccharomyces pombe genome stress by visualizing end-binding protein Ku
Copyright policy )Monitoring Schizosaccharomyces pombe genome stress by visualizing end-binding protein Ku
ABSTRACT Studies of genome stability have exploited visualization of fluorescently tagged proteins in live cells to characterize DNA damage, checkpoint, and repair responses. In this report, we describe a new tool for fission yeast, a tagged version of the end-binding protein Pku70 which is part of the KU protein complex. We compare Pku70 localization to other markers upon treatment to various genotoxins, and identify a unique pattern of distribution. Pku70 provides a new tool to define and characterize DNA lesions and the repair response.
DNA Repair, QH301-705.5, Science, Methods & Techniques, Q, Fluorescent Antibody Technique, fission yeast, Time-Lapse Imaging, Genomic Instability, DNA-Binding Proteins, Protein Transport, ku, Schizosaccharomyces, microscopy, dna damage, Schizosaccharomyces pombe Proteins, Biology (General), Genome, Fungal, genome stability, DNA Damage, Protein Binding
DNA Repair, QH301-705.5, Science, Methods & Techniques, Q, Fluorescent Antibody Technique, fission yeast, Time-Lapse Imaging, Genomic Instability, DNA-Binding Proteins, Protein Transport, ku, Schizosaccharomyces, microscopy, dna damage, Schizosaccharomyces pombe Proteins, Biology (General), Genome, Fungal, genome stability, DNA Damage, Protein Binding
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).7 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Average impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!