<script type="text/javascript">
<!--
document.write('<div id="oa_widget"></div>');
document.write('<script type="text/javascript" src="https://www.openaire.eu/index.php?option=com_openaire&view=widget&format=raw&projectId=undefined&type=result"></script>');
-->
</script>

COPY SCRIPT

For further information contact us at helpdesk@openaire.eu

White matter volumes and periventricular white matter hyperintensities in aging and dementia

descriptionPublicationkeyboard_double_arrow_right Article 22 Feb 2000 English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:Neurology, volume 54, pages 838-842 (issn: 0028-3878, eissn: 1526-632X,

Authors: Charles D. Smith; William R. Markesbery; David A. Snowdon; Hao Wang;

doi: 10.1212/wnl.54.4.838

pmid: 10690973

White matter volumes and periventricular white matter hyperintensities in aging and dementia

- Summary
- Subjects
- Metrics

Abstract

To determine the relationship between MRI periventricular white matter hyperintensities, cerebral white matter volumes, neuropathologic findings, and cognitive status in aged individuals.The significance of periventricular white matter hyperintensities seen on MR images in aged individuals remains controversial. The Nun Study is a longitudinal cohort aging study in which all 678 initially enrolled participants agreed to autopsy neuropathologic examination.We used MRI to measure white matter volumes of the cerebral hemispheres in 52 formaldehyde-fixed brains for correlation with white matter and neocortical pathology, postmortem MRI observations, and cognitive measures.Reduced white matter volume is associated with dementia, but periventricular white matter hyperintensities were not related to white matter volume, stroke, or dementia.Our results do not support the hypothesis that periventricular hyperintensities seen on MR images have deleterious consequences in these aged individuals.

Related Organizations

Albert B. Chandler Hospital
United States
University of Kentucky
United States
University of Kentucky HealthCare
United States

Keywords

Aged, 80 and over, Psychiatric Status Rating Scales, Aging, Alzheimer Disease, Brain, Humans, Neuropsychological Tests, Aged

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	129
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%