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Lack of efficacy of phosphatidylcholine in ataxias

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1988 Italy English Publisher:Ovid Technologies (Wolters Kluwer Health)Journal:Neurology, volume 38, pages 649-649 (issn: 0028-3878, eissn: 1526-632X,

Authors: SORBI, SANDRO; PIACENTINI, SILVIA; MARINI, PAOLO; DE SCISCIOLO, GIUSEPPE; AMANTINI, ALDO; AMADUCCI, LUIGI;

doi: 10.1212/wnl.38.4.649

pmid: 3352929

handle: 2158/323342

Lack of efficacy of phosphatidylcholine in ataxias

- Summary
- Subjects
- Metrics

Abstract

We gave phosphatidylcholine orally at a daily dosage of 9 grams for 4 years to 20 subjects with Friedreich's ataxia (FA) and 24 with olivopontocerebellar atrophy (OPCA). There was no clinical improvement during the follow-up compared with 12 ataxic patients (six FA and six OPCA) who did not receive any treatment. A 6-month trial at a double dose did not have any significant effect. This study indicates that phosphatidylcholine does not change the natural course of ataxias.

Country

Italy

Related Organizations

Università degli studi di Salerno
Italy
University of Florence
Italy

Keywords

Male, Olivopontocerebellar Atrophies, Phosphatidylcholines, Humans, Ataxia, Female

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