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Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH)in Vitro

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1976 English Publisher:The Endocrine SocietyJournal:Endocrinology, volume 98, pages 289-294 (issn: 0013-7227, eissn: 1945-7170,

Authors: Andrew V. Schally; Andrew V. Schally; Esther J. Coy; Esther J. Coy; David H. Coy; David H. Coy; Muriel Savary; +3 Authors

doi: 10.1210/endo-98-2-289

pmid: 765119

Inhibition of Luteinizing Hormone Release by Analogs of Luteinizing Hormone-Releasing Hormone (LHRH)in Vitro

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Abstract

Sixteen synthetic analogs of LH-releasing hormone (LHRH) were tested for their ability to inhibit the stimulation of LH release induced by 3 X 10(-9)M LHRH in anterior pituitary cells in monolayer culture. Half-maximal inhibition of LHRH-induced LH release was obtained with 7 analogs at concentrations which ranged from 3 X 10(-6)M to 3 X 10(-5)M. None of these seven analogs had significant LH-releasing activity at concentrations up to 10-5M. Nine analogs had no detectable antagonistic activity when tested in up to a 3000-fold molar ratio of analog to LHRH.

Related Organizations

Tulane University
United States
Université Laval
Canada

Keywords

Gonadotropin-Releasing Hormone, Structure-Activity Relationship, Dose-Response Relationship, Drug, Pituitary Gland, Anterior, Pituitary Gland, Animals, Luteinizing Hormone, Cells, Cultured, Rats

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