The concept of entropy spatial-energy interactions is used to reflect the similar views on the statistical thermodynamics of entropy. The resulting nomogram is obtained for estimating the entropy of various processes. The authors discuss the variety of manifestations of entropy, including the biochemical processes in the economy. In living systems the entropy increase is offset by the negative entropy, which is formed through interaction with the external environment. Thus, a living system is an open system. And businesses can no longer be isolated systems without exchange process and the relationship with the external environment. The role of the external system reducing the increase in business entropy must perform, for example, relevant state and public structures, functionally separated from the business. Perhaps, inevitable process in this direction can be de-monopolization of the largest economic structures, carried out “on top” in an evolutionary way. In thermodynamics it is considered that the uncontrolled growth of entropy leads to the termination of any macroeconomic systems, that is, to their death. Therefore, the main task is to search for the methods of reducing the uncontrolled growth of entropy in big business. In addition, these critical numbers of entropy relate mainly to big business. A simple reduction of the number of its employees may not give the real result of a decrease in entropy. So, reduction of the number of employees by 10 % would decrease the entropy of only 0.6 % and this despite the general negative effects of unemployment, which inevitably accompanies such a process. Therefore, such sermonettes not controlled either by the state or society are aimed to reduce the entropy of the business in a more real way of demonopolization without optimization (that is, without reducing the total number of employees). Now the scientific world is puzzled by the intensification of technological processes on the basis of energy-saving technology, for example. This technique P-parameter can also be used in this promising direction.