Raising software abstraction and re-use levels are key success factors for producing quality software products. Model-driven architecture (MDA) is an OMG initiative following this trend by mapping a conceptual model of application specified in platform independent model (PIM), to one or more platform specific models (PSM) automatically. Because there is little previous work tackling the development problem from specification through to implementation, this paper proposes End to End Development engineering (E2EDE) method using MDA methodology. E2EDE is intended to fill the mapping gap between PIM and PSM in MDA. The notion of variability is utilized from software product line and used to model design decisions in PSM. PIM is equipped with Nonfunctional requirements which borrowed from Design pattern to inform design decisions; thereby guiding the mapping process. In addition we have developed a strategic PSM for messaging systems can be configured to produce different applications such as the helpdesk system which is used as a case study.