Heavy-chain diseases

descriptionPublicationkeyboard_double_arrow_right Part of book or chapter of book , Article 01 Dec 1999 English Publisher:Informa UK LimitedJournal:Hematology/Oncology Clinics of North America, volume 13, pages 1,281-1,294 (issn: 0889-8588,

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Authors: J P, Fermand; J C, Brouet;

doi: 10.1201/b13347-35 , 10.1016/s0889-8588(05)70127-1

pmid: 10626151

Heavy-chain diseases

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Abstract

This review underscores the diversity of the structural and genetic abnormalities of HCD proteins and of the clinicopathologic features of the underlying lymphoproliferative disorders. Cells producing HCD may, however, all derive from a common normal precursor, which could be a rare B cell in the process of immunoglobulin gene somatic mutation within the germinal center.

Related Organizations

Assistance Publique -Hopitaux De Paris
France
Hôpital Saint-Louis
France

Keywords

B-Lymphocytes, Humans, Immunoglobulin Heavy Chains, Heavy Chain Disease

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