Moxonidine, a Mixed a2‐Adrenergic and Imidazoline Receptor Agonist, Identifies a Novel Adrenergic Target for Spinal Analgesia
Copyright policy )Moxonidine, a Mixed a2‐Adrenergic and Imidazoline Receptor Agonist, Identifies a Novel Adrenergic Target for Spinal Analgesia
Abstract: Moxonidine is a mixed a2‐adrenergic and imidazoline receptor agonist with an improved side effect profile compared to clonidine. Intrathecal (i.t.) moxonidine has been found to possess analgesic activity that, in contrast to the majority of a2‐adrenoceptor (a2AR) agonists, does not require activation of the a2AAR subtype, which mediates many of the side effects associated with a2AR use. In addition, moxonidine (i.t.) interacts in a synergistic manner with opioid agonists and this synergy is retained in neuropathic pain states. Moxonidine may therefore be clinically useful in the treatment of chronic neuropathic pain, either alone or as a coadjuvant with opioids.
- University of Minnesota System United States
- University of Minnesota United States
- University of Minnesota Morris United States
Morphine, Receptors, Drug, Imidazoles, Pain, Drug Synergism, Anesthesia, Spinal, Analgesics, Opioid, Receptors, Adrenergic, alpha-2, Animals, Humans, Protein Isoforms, Imidazoline Receptors, Analgesia, Adrenergic alpha-Agonists
Morphine, Receptors, Drug, Imidazoles, Pain, Drug Synergism, Anesthesia, Spinal, Analgesics, Opioid, Receptors, Adrenergic, alpha-2, Animals, Humans, Protein Isoforms, Imidazoline Receptors, Analgesia, Adrenergic alpha-Agonists
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