In the “Revue de Thérapeutique,” November 15th, 1894, mention is made of this method of Flechsig in the review by Dr. A. Sallard of a treatise by C. Salzburg (Leipzig, 1894) on the subject. Attention is drawn to the variable results obtained by prevailing practice in the treatment of epilepsy, these results ranging between 10 per cent. and 70 per cent. of cures. Flechsig's method consists in the administration of opium in the first instance, commencing with doses of some ⅚ grain pro die of powdered opium or of its extract; this dose is distributed over the day. The quantity of opium is then increased by ⅙ grain each day till a maximum of four or five grains is taken each day. At the end of six weeks the opium treatment is completely suppressed, and the bromide administration is then begun. This is given in large doses, some 75–105 grains pro die, and it is continued for at least two months. The attacks generally yield to the first doses of the bromides.