Is There a Lithium Withdrawal Syndrome?
Copyright policy )Is There a Lithium Withdrawal Syndrome?
Patients who discontinued lithium after a mean of 29 ± 21 months prophylaxis were compared with a similar group who were not taking the drug; all had only been in hospital once, and satisfied DSM-III criteria for mania. During the first three months following withdrawal of lithium, significantly more patients relapsed than in the control group; after this period, the rate was identical. These findings suggest that lithium withdrawal exists as a clinical phenomenon and that a period of lithium treatment does not improve the long-term prognosis, once the drug has been stopped.
- Royal Edinburgh Hospital United Kingdom
- University of Edinburgh United Kingdom
- NHS Lothian United Kingdom
Adult, Bipolar Disorder, Time Factors, Recurrence, Humans, Lithium, Retrospective Studies, Substance Withdrawal Syndrome
Adult, Bipolar Disorder, Time Factors, Recurrence, Humans, Lithium, Retrospective Studies, Substance Withdrawal Syndrome
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