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Best PEEP trials are dependent on tidal volume

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 02 May 2018 English Publisher:Springer Science and Business Media LLCJournal:Critical Care, volume 22 (eissn: 1364-8535,

Authors: Todd W. Rice; Andrew C. McKown; Matthew W. Semler;

doi: 10.1186/s13054-018-2047-4

pmid: 29720277

pmc: PMC5930668

Best PEEP trials are dependent on tidal volume

- Summary
- Subjects
- Metrics

Abstract

Determining the optimal positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome remains an area of active investigation. Most trials individualizing PEEP optimize one physiologic parameter (e.g., driving pressure) by titrating PEEP while holding other ventilator settings constant. Optimal PEEP, however, may depend on the tidal volume, and changing the tidal volume with which a best PEEP trial is performed may lead to different best PEEP settings in the same patient.ClinicalTrials.gov, NCT02871102. Registered on 12 August 2016.

Related Organizations

Vanderbilt University Medical Center
United States

Keywords

Positive-Pressure Respiration, Respiratory Distress Syndrome, Letter, RC86-88.9, Tidal Volume, Humans, Medical emergencies. Critical care. Intensive care. First aid, Respiration, Artificial

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	12
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average