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Mechanisms of ubiquitin transfer by the anaphase-promoting complex

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2009 English Publisher:Springer Science and Business Media LLCJournal:Journal of Biology, volume 8, page 92 (issn: 1475-4924, Copyright policy )
Authors: Matyskiela, Mary E; Rodrigo-Brenni, Monica C; Morgan, David O;

doi: 10.1186/jbiol184

pmid: 19874575

pmc: PMC2790831

Mechanisms of ubiquitin transfer by the anaphase-promoting complex

Abstract

The anaphase-promoting complex (APC) is a ubiquitin-protein ligase required for the completion of mitosis in all eukaryotes. Recent mechanistic studies reveal how this remarkable enzyme combines specificity in substrate binding with flexibility in ubiquitin transfer, thereby allowing the modification of multiple lysines on the substrate as well as specific lysines on ubiquitin itself.

Related Organizations
Keywords

Ubiquitin, Ubiquitination, Mitosis, Ubiquitin-Protein Ligase Complexes, Review, Biological Sciences, Biological, Models, Biological, Anaphase-Promoting Complex-Cyclosome, Substrate Specificity, Models, Biocatalysis, Biochemistry and Cell Biology, Generic health relevance, Developmental Biology

  • BIP!
    Impact byBIP!
    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 26
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Top 10%
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Top 10%
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
26
Average
Top 10%
Top 10%
Green
gold