The latest sepsis guideline has emphasized early resuscitative fluid management [1]. Early goal-directed therapy (EGDT) has been shown to improve 28-day mortality in recent studies [2],[3]. This strategy was based on improving tissue perfusion and oxygenation in spite of other supportive and therapeutic measures. Technically and historically, central venous pressure (CVP) measurement is one of the most dependent methods to estimate fluid responsiveness and intravascular volume status on resuscitation. The Surviving Sepsis Campaign (SSC) guidelines recommended goal levels of CVP 8 to 12 mmHg in order to obtain appropriate tissue perfusion [1]. In this study, we objected to re-evaluate effectiveness of a fluid resuscitation strategy in sepsis, comparing the effect of patients' daily fluid balances (DFB) and CVP on patients' survival.