Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function
Copyright policy )Insulin-like growth factors and insulin-like growth factor binding proteins in mammary gland function
Insulin-like growth factor (IGF)-mediated proliferation and survival are essential for normal development in the mammary gland during puberty and pregnancy. IGFs interact with IGF-binding proteins and regulate their function. The present review focuses on the role of IGFs and IGF-binding proteins in the mammary gland and describes how modulation of their actions occurs by association with hormones, other growth factors and the extracellular matrix. The review will also highlight the involvement of the IGF axis in breast cancer.
- School of Biological Sciences University of Manchester United Kingdom
- University of Manchester United Kingdom
- University of Manchester United Kingdom
- University of Manchester United Kingdom
- University of Manchester United Kingdom
Mammary gland, Apoptosis, Breast Neoplasms, Estrogens, Matrix Metalloproteinases, Extracellular Matrix, Insulin-Like Growth Factor Binding Proteins, Breast cancer, Insulin-like growth factor binding proteins, Somatomedins, Animals, Humans, Insulin-like growth factor, Breast, Cell Division
Mammary gland, Apoptosis, Breast Neoplasms, Estrogens, Matrix Metalloproteinases, Extracellular Matrix, Insulin-Like Growth Factor Binding Proteins, Breast cancer, Insulin-like growth factor binding proteins, Somatomedins, Animals, Humans, Insulin-like growth factor, Breast, Cell Division
selected citations These citations are derived from selected sources.This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).85 popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.Top 10% influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).Top 10% impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.Top 10%
Citations provided by BIP!Popularity provided by BIP!