Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
Copyright policy )Tyrosine kinase signalling in breast cancer: ErbB family receptor tyrosine kinases
ERBB family receptor tyrosine kinases are overexpressed in a significant subset of breast cancers. One of these receptors, HER2/neu, or ErbB-2, is the target for a new rational therapeutic antibody, Herceptin. Other inhibitors that target this receptor, and another family member, the epidermal growth factor (EGF) receptor, are moving into clinical trials. Both of these receptors are sometimes overexpressed in breast cancer, and still subject to regulation by hormones and other physiological regulators. Optimal use of therapeutics targeting these receptors will require consideration of the several modes of regulation of these receptors and their interactions with steroid receptors.
- School of Medicine Yale University United States
- Yale University United States
- YALE UNIVERSITY
Transcriptional Activation, Epidermal Growth Factor, Receptor, ErbB-2, Genes, erbB, Gene Amplification, Antibodies, Monoclonal, Gene Expression Regulation, Developmental, Breast Neoplasms, Review, Protein-Tyrosine Kinases, Trastuzumab, Antibodies, Monoclonal, Humanized, ErbB Receptors, Gene Expression Regulation, Neoplastic, Transforming Growth Factors, Humans, Female, Biomarkers, Signal Transduction
Transcriptional Activation, Epidermal Growth Factor, Receptor, ErbB-2, Genes, erbB, Gene Amplification, Antibodies, Monoclonal, Gene Expression Regulation, Developmental, Breast Neoplasms, Review, Protein-Tyrosine Kinases, Trastuzumab, Antibodies, Monoclonal, Humanized, ErbB Receptors, Gene Expression Regulation, Neoplastic, Transforming Growth Factors, Humans, Female, Biomarkers, Signal Transduction
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