Imaging biochemistry: applications to breast cancer
Copyright policy )Imaging biochemistry: applications to breast cancer
The use of magnetic resonance spectroscopy (MRS) to investigate breast tumour biochemistry in vivo is reviewed. To this end, results obtained both from patients in vivo and from tumour extracts and model systems are discussed. An association has been observed between transformation and an increase in phosphomonoesters (PMEs) detected in the 31P MRS spectrum, as well as an increase in choline-containing metabolites detected in the 1H spectrum. A decrease in PME content after treatment is associated with response to treatment as assessed by tumour volume. Experiments in model systems aimed at understanding the underlying biochemical processes are presented, as well as data indicating the usefulness of MRS in monitoring the uptake and metabolism of some chemotherapeutic agents.
- University of California United States
- Institute of Cancer Research United Kingdom
Oncology and Carcinogenesis, Nude, Mice, Nude, Breast Neoplasms, Adenocarcinoma, Cell Line, Experimental, Mice, choline, Breast Cancer, Animals, Humans, Oncology & Carcinogenesis, Phospholipids, Cancer, Nutrition, screening and diagnosis, P-31 MRS, Biomedical and Clinical Sciences, Mammary Neoplasms, Mammary Neoplasms, Experimental, Phosphorus Isotopes, Oncology and carcinogenesis, phosphomonoesters, magnetic resonance spectroscopy, Magnetic Resonance Imaging, 4.1 Discovery and preclinical testing of markers and technologies, Detection, Biomedical Imaging, Female, Energy Metabolism, (1H) MRS
Oncology and Carcinogenesis, Nude, Mice, Nude, Breast Neoplasms, Adenocarcinoma, Cell Line, Experimental, Mice, choline, Breast Cancer, Animals, Humans, Oncology & Carcinogenesis, Phospholipids, Cancer, Nutrition, screening and diagnosis, P-31 MRS, Biomedical and Clinical Sciences, Mammary Neoplasms, Mammary Neoplasms, Experimental, Phosphorus Isotopes, Oncology and carcinogenesis, phosphomonoesters, magnetic resonance spectroscopy, Magnetic Resonance Imaging, 4.1 Discovery and preclinical testing of markers and technologies, Detection, Biomedical Imaging, Female, Energy Metabolism, (1H) MRS
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