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Cell-cell interactions in synovitis. Endothelial cells and immune cell migration.

Name: Cell-cell interactions in synovitis. Endothelial cells and immune cell migration.
Keywords: Arthritis, Rheumatoid, Synovitis, Cell Movement, Cell Adhesion, Leukocytes, Animals, Humans, Orvostudományok, Review, Cell Communication

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2000 Hungary English Publisher:BioMed CentralJournal:Arthritis research, volume 2 (issn: 1465-9905,

Copyright policy )Funded by:NIH | IL 4 AND IL 13 GENE THERA..., NIH | CHEMOTACTIC CYTOKINES IN ..., NIH | PILOT STUDY--JRA LEUKOCYT...

Authors: Zoltán Szekanecz; Alisa E. Koch; Alisa E. Koch;

doi: 10.1186/ar114

pmid: 11094450

pmc: PMC130138

handle: 2437/90186

Cell-cell interactions in synovitis. Endothelial cells and immune cell migration.

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Abstract

Leukocyte ingress into the synovium is a key process in the pathogenesis of rheumatoid arthritis and other inflammatory conditions. In this review, the role of endothelial cells in leukocyte extravasation will be discussed, including the role of the most relevant cellular adhesion molecules. These molecules play an important role in mediating leukocyte--endothelial interactions. It is likely that different adhesive pathways are involved in different steps of leukocyte adhesion to and migration through endothelia. Targeting of pathological endothelial function, including leukocyte--endothelial adhesion, may be useful for the future management of inflammatory arthritis.

Country

Hungary

Related Organizations

Northwestern State University
United States
University of Debrecen
Hungary
University and National Library University of Debrecen
Hungary

Keywords

Arthritis, Rheumatoid, Synovitis, Cell Movement, Cell Adhesion, Leukocytes, Animals, Humans, Orvostudományok, Review, Cell Communication, Endothelium, Vascular, Klinikai orvostudományok

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	41
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average