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The role of CCR5 in HCV infection

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2010Publisher:Springer Science and Business Media LLCJournal:European Journal of Medical Research, volume 15, page 97 (issn: 2047-783X,

Authors: Martin Coenen; Jacob Nattermann;

doi: 10.1186/2047-783x-15-3-97

pmid: 20452893

pmc: PMC3352223

The role of CCR5 in HCV infection

- Summary
- Subjects
- Metrics

Abstract

Efficient recruitment and activation of immuno-competent cells is crucial for an effective immune response to hepatitis C virus (HCV) infection. Chemokines and chemokine receptors have been shown to be critically involved in these processes. The CCR5 chemokine receptor is expressed on several cells of the immune system and has been suggested to influence the susceptibility to HCV infection as well as natural course and progression of hepatitis C. However, these reports are still controversial. This review will summarize and discuss the available data regarding the potential role of CCR5 and its ligands in hepatitis C.

Related Organizations

University of Bonn
Germany
University of Bonn
Germany

Keywords

Receptors, CCR5, chemokine, R, chemokine receptor, Review, Hepatitis C, immune response, HCV, Medicine, Humans, CCR5, Chemokine CCL5

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	23
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%