Semantic Category Disambiguation (SCD) is the task of assigning the appropriate semantic category to given spans of text from a fixed set of candidate categories, for example Protein to "Fibrin". SCD is relevant to Natural Language Processing tasks such as Named Entity Recognition, coreference resolution and coordination resolution. In this work, we study machine learning-based SCD methods using large lexical resources and approximate string matching, aiming to generalise these methods with regard to domains, lexical resources and the composition of data sets. We specifically consider the applicability of SCD for the purposes of supporting human annotators and acting as a pipeline component for other Natural Language Processing systems.While previous research has mostly cast SCD purely as a classification task, we consider a task setting that allows for multiple semantic categories to be suggested, aiming to minimise the number of suggestions while maintaining high recall. We argue that this setting reflects aspects which are essential for both a pipeline component and when supporting human annotators. We introduce an SCD method based on a recently introduced machine learning-based system and evaluate it on 15 corpora covering biomedical, clinical and newswire texts and ranging in the number of semantic categories from 2 to 91. With appropriate settings, our system maintains an average recall of 99% while reducing the number of candidate semantic categories on average by 65% over all data sets.Machine learning-based SCD using large lexical resources and approximate string matching is sensitive to the selection and granularity of lexical resources, but generalises well to a wide range of text domains and data sets given appropriate resources and parameter settings. By substantially reducing the number of candidate categories while only very rarely excluding the correct one, our method is shown to be applicable to manual annotation support tasks and use as a high-recall component in text processing pipelines. The introduced system and all related resources are freely available for research purposes at: https://github.com/ninjin/simsem.