descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 29 Jan 2010 English Publisher:Springer Science and Business Media LLCJournal:Journal of Neuroinflammation, volume 7 (eissn: 1742-2094,

Authors: ALBONI, Silvia; Cervia, D; Sugama, S; Conti, B.;

doi: 10.1186/1742-2094-7-9

pmid: 20113500

pmc: PMC2830964

handle: 11380/1062988

Interleukin 18 in the CNS

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Abstract

AbstractInterleukin (IL)-18 is a cytokine isolated as an important modulator of immune responses and subsequently shown to be pleiotropic. IL-18 and its receptors are expressed in the central nervous system (CNS) where they participate in neuroinflammatory/neurodegenerative processes but also influence homeostasis and behavior. Work on IL-18 null mice, the localization of the IL-18 receptor complex in neurons and the neuronal expression of decoy isoforms of the receptor subunits are beginning to reveal the complexity and the significance of the IL-18 system in the CNS. This review summarizes current knowledge on the central role of IL-18 in health and disease.

Related Organizations

Nippon Medical School
Japan
SCRIPPS RESEARCH INSTITUTE
Tuscia University
Italy
Scripps Research Institute
United States
Nippon Medical School
Japan

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Keywords

Central Nervous System, Inflammation, Receptors, Interleukin-8, Mental Disorders, Immunology, Interleukin-18, Neurodegenerative Diseases, Review, IL-18 brain Physiology Pathology, Cellular and Molecular Neuroscience, Autoimmune Diseases of the Nervous System, Neurology, Animals, Humans, Neurology. Diseases of the nervous system, Microglia, RC346-429, Stress, Psychological, Signal Transduction

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