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Genetics of Tobacco Use

descriptionPublicationkeyboard_double_arrow_right Article , Other literature type 01 Jan 2004 United States Publisher:E.U. European PublishingJournal:Tobacco Induced Diseases, volume 2, page 81 (issn: 1617-9625,

Authors: Maserejian, Nancy Nairi; Zavras, Athanasios I.;

doi: 10.1186/1617-9625-2-2-81

pmid: 19570274

pmc: PMC2671538

Genetics of Tobacco Use

- Summary
- Subjects
- Metrics

Abstract

The worldwide prevalence of tobacco use is widespread, resulting in nearly 4.5 million deaths every year. Nicotine is addictive and has psychopharmacological effects that maintain the use of tobacco products. Several studies have documented a strong hereditary component to tobacco use. The present article reviews results from twin and adoption studies and proceeds to present association studies of specific genes that may be involved in tobacco use. Cholinergic receptor nicotinic beta polypeptide 2, serotonin receptor and transporter genes, dopamine receptor and transporter genes, and the cytochrome P450A6 gene are reviewed. Linkage studies help to identify regions of the genome that may be worth further investigation. The paper concludes with a discussion of the limitations of genetic research and the future of genetic epidemiology in this domain.

Country

United States

Related Organizations

Harvard University
United States
Department of Epidemiology Harvard School of Public Health
United States

Keywords

RC705-779, Public Health, Environmental and Occupational Health, 610, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, Medicine (miscellaneous), Review, smoking, smoking behavior, Health(social science), Diseases of the respiratory system, 616, epidemiology, cotinine, dopamine, polymorphisms, nicotine dependence, RC254-282, nicotine

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	3
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average