SummaryThe authors review the studies which have been carried out on fenoprofen. Fenoprofen has been demonstrated to have anti-inflammatory, analgesic and antipyretic activity in both animals and man. It is an effective and well tolerated agent in the symptomatic treatment of patients with rheumatoid arthritis, degenerative joint disease, ankylosing spondylitis, acute gout and non-articular rheumatism. Fenoprofen is also useful in the symptomatic treatment of a variety of conditions associated with pain and fever.The main adverse reactions have been minor skin rashes and gastro-intestinal disturbances. Although less irritating than aspirin, fenoprofen should be used with caution in patients with a history of peptic ulcer disease. The risk-to-benefit ratio suggests that fenoprofen will be a useful therapeutic agent.