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Bronchiectasis is increasing in prevalence worldwide, yet current treatments available are limited to those alleviating symptoms and reducing exacerbations. The pathogenesis of the disease and the inflammatory, infective and molecular drivers of disease progression are not fully understood, making the development of novel treatments challenging. Understanding the role bacteria play in disease progression has been enhanced by the use of next-generation sequencing techniques such as 16S rRNA sequencing. The microbiome has not been extensively studied in bronchiectasis, but existing data show lung bacterial communities dominated byPseudomonas,HaemophilusandStreptococcus, while exhibiting intraindividual stability and large interindividual variability.Pseudomonas-andHaemophilus-dominated microbiomes have been shown to be linked to severe disease and frequent exacerbations. Studies completed to date are limited in size and do not fully represent all clinically observed disease subtypes. Further research is required to understand the microbiomes role in bronchiectasis disease progression. This review discusses recent developments and future perspectives on the lung microbiome in bronchiectasis.
RC705-779, Microbiota, Haemophilus, 610, Streptococcus, Anti-Bacterial Agents, Bronchiectasis, Diseases of the respiratory system, Risk Factors, Pseudomonas, Lung Science Conference Review, Host-Pathogen Interactions, Disease Progression, Animals, Humans, Lung
RC705-779, Microbiota, Haemophilus, 610, Streptococcus, Anti-Bacterial Agents, Bronchiectasis, Diseases of the respiratory system, Risk Factors, Pseudomonas, Lung Science Conference Review, Host-Pathogen Interactions, Disease Progression, Animals, Humans, Lung
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influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically). | Top 10% | |
impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network. | Top 1% |