Aim: Analyze clinical-radiological features and clinical course of M.kansasii pulmonary disease compared to other NTMs Methods: Retrospective, descriptive study of NTM pulmonary disease from 1997 to 2016. 2007 ATS criteria were fulfilled. We evaluated:demographic data, risk factors, symptomatology, radiology, coinfection, recurrence and overall mortality per year Results: 327cases of NTM lung disease:274(83.7%)M. Kansasii and 53(16.3%)other NTM. Comparison between them are seen in figure1.M. Kansasii group, patients were younger, males, smokers and with cancer. No differences were found in symptoms.M. kansasii was associated with more cavitation, unilaterality and upper lobes predominance. Other NTMs infections were associated with bronchiectasis, nodules or “tree in bud” infiltrates with middle lobes predominance and more coinfection. Rates of recurrence were similar in both groups and the overall-1year mortality rate, including NTMosis-related mortality and other causes mortality. Sputum conversion was maintained in 85.8% of M.kansasii vs 75.5% in other NTM and radiological resolution in 60%vs39% Conclusions: There are relevant differences between M. Kansasii lung infections and those caused by other NTMs:1. They appear to occur more in male smokers, in the fifth decade and with a history of neoplasia 2. They are associated with cavitation, unilaterality and upper lobe predominance 3. Sputum conversion and radiological resolution rates are higher