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ABO blood group system and bone marrow transplantation

Name: ABO blood group system and bone marrow transplantation
Keywords: Adult, Graft Rejection, Immunosuppression Therapy, Male, Leukemia, Adolescent, Daunorubicin, Cytarabine, Anemia, Aplastic, Graft vs Host Disease

descriptionPublicationkeyboard_double_arrow_right Article 01 Aug 1977Publisher:American Society of HematologyJournal:Blood, volume 50, pages 185-194 (issn: 0006-4971, eissn: 1528-0020,

Authors: Peter M. Falk; Stephen A. Feig; Won Jin Ho; C Rippee; R. S. Sparkes; Robert Peter Gale;

doi: 10.1182/blood.v50.2.185.bloodjournal502185 , 10.1182/blood.v50.2.185.185

pmid: 326317

ABO blood group system and bone marrow transplantation

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Abstract

The role of the ABO blood group system in determining the outcome of bone marrow transplantation was investigated in 53 patients with aplastic anemia and acute leukemia grafted from HLA-identical siblings. There was no correlation between ABO compatibility and marrow engraftment, graft rejection, or graft-versus-host disease. In 5 recipients with antibodies prior to transplantation to antigens of the ABH system present on the cells of their donors, plasma exchange and antibody absorption in vivo were effective in permitting engraftment of ABO-incompatible bone marrow. These findings indicate that the ABO system is not a clinically significant barrier to successful bone marrow transplantation in otherwise histocompatible individuals.

Related Organizations

University of Chicago
United States

Keywords

Adult, Graft Rejection, Immunosuppression Therapy, Male, Leukemia, Adolescent, Daunorubicin, Cytarabine, Anemia, Aplastic, Graft vs Host Disease, Bone Marrow Cells, ABO Blood-Group System, Isoantibodies, Histocompatibility, Humans, Female, Thioguanine, Cyclophosphamide, Antilymphocyte Serum, Bone Marrow Transplantation

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	160
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Average
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 1%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%