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ceRNAs and ceRNA Networks in Normal and Malignant Hematopoiesis and Their Therapeutic Implications

Name: ceRNAs and ceRNA Networks in Normal and Malignant Hematopoiesis and Their Therapeutic Implications
Creator: Pier Paolo Pandolfi
Keywords: 0301 basic medicine, 0303 health sciences, 03 medical and health sciences, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 15 Nov 2013 English Publisher:American Society of HematologyJournal:Blood, volume 122, pages SCI-30 (issn: 0006-4971, eissn: 1528-0020,

Authors: Pier Paolo Pandolfi;

doi: 10.1182/blood.v122.21.sci-30.sci-30

ceRNAs and ceRNA Networks in Normal and Malignant Hematopoiesis and Their Therapeutic Implications

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Abstract

Abstract We will discuss exciting new data regarding the role of pseudogenes, long intergenic non-coding RNAs (lincRNAs) and miRNAs in the pathogenesis of leukemia and lymphoma, as also studied in vivo in the mouse, and their therapeutic implications. We will also focus on competing endogenous RNAs (ceRNAs), circular(circ)-ceRNAs and pseudo-ceRNAs and give important attention to how understanding their cross-talk and the ceRNA language will facilitate efforts to deconvolute ceRNA networks and their role in the pathogenesis of hematopoietic malignancies. Disclosures: No relevant conflicts of interest to declare.

Related Organizations

Harvard University
United States
Beth Israel Deaconess Medical Center
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