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Blood
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Blood
Article . 2019 . Peer-reviewed
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Blood
Article . 2019
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Blood
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Primary polymerization prevention

descriptionPublicationkeyboard_double_arrow_right Article 25 Apr 2019 English Publisher:American Society of HematologyJournal:Blood, volume 133, pages 1,797-1,798 (issn: 0006-4971, eissn: 1528-0020, Copyright policy )
Authors: Martin H Steinberg;

doi: 10.1182/blood-2019-02-898767

pmid: 31023742

Primary polymerization prevention

Abstract

In this issue of Blood, Howard et al report a phase 1/2 study of voxelotor (GBT440) in sickle cell anemia. This drug binds to the α-globin chain of hemoglobin and increases hemoglobin-oxygen affinity, thereby decreasing the polymerization tendency of deoxygenated sickle hemoglobin (HbS). Treated patients had a median 1 g/dL increase of hemoglobin concentration, and markers of hemolysis were decreased.1

Related Organizations
Keywords

Patients, Benzaldehydes, Pyrazines, Humans, Pyrazoles, Anemia, Sickle Cell, Polymerization

  • BIP!
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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 3
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
3
Average
Average
Average
bronze
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