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Chronic lymphocytic leukemia and the Warburg effect

Name: Chronic lymphocytic leukemia and the Warburg effect
Creator: Carol Moreno
Keywords: Proto-Oncogene Proteins c-myc, 03 medical and health sciences, 0302 clinical medicine, Receptors, Notch, 13. Climate action, Humans, Stromal Cells, Glycolysis, Leukemia, Lymphocytic, Chronic, B-Cell, 3. Good health

descriptionPublicationkeyboard_double_arrow_right Article 28 May 2015 English Publisher:American Society of HematologyJournal:Blood, volume 125, pages 3,368-3,369 (issn: 0006-4971, eissn: 1528-0020,

Authors: Carol Moreno;

doi: 10.1182/blood-2015-04-636332

pmid: 26022050

Chronic lymphocytic leukemia and the Warburg effect

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Abstract

In this issue of Blood, Jitschin et al demonstrate a microenvironmental glycolytic shift in chronic lymphocytic leukemia (CLL) cells mediated by Notch-c-Myc signaling. Interfering in the Notch-c-Myc pathway and reprogramming glycolytic metabolism could contribute to overcoming drug resistance in CLL.

Related Organizations

Hospital de Sant Pau
Spain

Keywords

Proto-Oncogene Proteins c-myc, Receptors, Notch, Humans, Stromal Cells, Glycolysis, Leukemia, Lymphocytic, Chronic, B-Cell

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	10
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Average
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average