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Tribbles in acute leukemia

descriptionPublicationkeyboard_double_arrow_right Article 23 May 2013Publisher:American Society of HematologyJournal:Blood, volume 121, pages 4,265-4,270 (issn: 0006-4971, eissn: 1528-0020,

Authors: Kai Ling Liang; Loveena Rishi; Karen Keeshan;

doi: 10.1182/blood-2012-12-471300

pmid: 23550039

Tribbles in acute leukemia

- Summary
- Subjects
- Related research
  (6)
- Metrics

Abstract

Abstract There is growing research interest in the mammalian Tribbles (Trib) family of serine/threonine pseudokinases and their oncogenic association with acute leukemias. This review is to understand the role of Trib genes in hematopoietic malignancies and their potential as targets for novel therapeutic strategies in acute myeloid leukemia and acute lymphoblastic leukemia. We discuss the role of Tribs as central signaling mediators in different subtypes of acute leukemia and propose that inhibition of dysregulated Trib signaling may be therapeutically beneficial.

Related Organizations

University of Glasgow
United Kingdom
University College Cork
Ireland

Keywords

Repressor Proteins, Leukemia, Myeloid, Acute, Calcium-Calmodulin-Dependent Protein Kinases, Intracellular Signaling Peptides and Proteins, Humans, Cell Cycle Proteins, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Protein Serine-Threonine Kinases

6 Research products, page 1 of 1

cDNA FLJ59723, highly similar to Tribbles homolog 3
2017IsRelatedTo
Tribbles homolog 1
2017IsRelatedTo
Tribbles homolog 2
2017IsRelatedTo
Tribbles homolog 3
2017IsRelatedTo
Tribbles homolog 2
2017IsRelatedTo
Tribbles homolog 3
2017IsRelatedTo

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	49
	popularity This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.	Top 10%
	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Top 10%