Innate immunity is the host defensive weapon against pathogens and this issue of Blood offers an interesting new bullet for the immune system gun by studying the role of Toll-like receptor 2 (TLR2) in megakaryocytic function; a field previously not explored. Beaulieu and colleagues provide evidence that inflammation, through TLR2, can increase megakaryocyte maturation and modulate its phenotype, contributing to our understanding of the interrelationship between inflammation and hemostasis.