THE IMMUNOCYTOCHEMICAL DEMONSTRATION OF CATHEPSIN D

descriptionPublicationkeyboard_double_arrow_right Article 01 Apr 1972 English Publisher:SAGE PublicationsJournal:Journal of Histochemistry & Cytochemistry, volume 20, pages 261-265 (issn: 0022-1554, eissn: 1551-5044,

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Authors: A R, Poole; J T, Dingle; A J, Barrett;

doi: 10.1177/20.4.261

pmid: 4113294

THE IMMUNOCYTOCHEMICAL DEMONSTRATION OF CATHEPSIN D

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Abstract

Cathepsin D has been demonstrated for the first time using an immunocytochemical approach and fluorescence microscopy. It has been localized in chick epithelium-like cells and in cells of synovia from joints of rabbits with an experimental arthritis. The enzyme is associated with lysosome-like organelles: it also has a diffuse cytoplasmic distribution in these cells.

Keywords

Immunodiffusion, Sheep, Staining and Labeling, Histocytochemistry, Arthritis, Immune Sera, Freund's Adjuvant, Fluorescent Antibody Technique, Epithelial Cells, Cathepsins, Epithelium, Microscopy, Fluorescence, Immunoglobulin G, Synovial Fluid, Animals, Rabbits, Lysosomes, Chickens

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