Epilepsy disorders are the most common treatable neurological disorders in childhood. Diagnosis and treatment of these disorders has improved over time. Children with epilepsy/seizure disorder are more likely to have or develop mental health and developmental comorbidities such as depression, anxiety, attention deficit hyperactivity disorder, learning disabilities, and developmental delay compared to children without epilepsy/seizure disorder. If seizures can be controlled, quality of life will improve. This article will review the current medical treatment for seizures and epilepsy, including medications, vagus nerve stimulation (VNS), dietary modifications, and surgical intervention.