Despite more than 40 years of clinical focus on the anterior cruciate ligament (ACL)–injured knee, a complete understanding of the injury mechanism, the optimal treatment plan (including reconstruction), and the best protocol for rehabilitation continue to stimulate much debate. Prevention efforts focused on ACL injuries have been laudable, but unfortunately, far too many young athletes still fall victim to this injury and are denied the opportunity to reach their full athletic potential. Besides the deleterious effects on an athletic career, many lifestyles are sadly altered as the knee deteriorates, and physical limitations are realized as osteoarthrosis becomes a reality. All too often, this occurs at a very young age. Consequently, ACL research remains a booming business whose results occupy a large portion of our scientific journals and sports medicine meeting programs. But as this issue of Sports Health demonstrates, progress is being made in the search for the best medical evidence to guide injury prevention programs, reconstructive techniques, rehabilitation efforts, and guidelines for return to sport. The review of 55 ACL injury soccer videos by Brophy et al2 suggests that it is safer for your knees to play an offensive position—70% of those ACL injuries occurred while defending (87% in females). Tackling was the most problematic skill, with 51% of injuries occurring during those maneuvers, most with contact. Not surprising! Cutting was the second most problematic skill, producing 15% of ACL tears. The take-home message for parents is try to convince your son’s or daughter’s coach that your kids belong on the offensive side of the ball because of their goal-scoring potential, and if they do end up on defense, teach them good tackling skills over and over and over again. If, however, your efforts at prevention are unsuccessful and an ACL tear occurs, find a surgeon who is willing to do an autograft reconstruction for your youngster, as emphasized by Wasserstein et al.4 Although the level of evidence of this study (level 3) is not the highest due to the available studies, the numbers presented are pretty convincing. In 1016 ACL-injured patients with 2- to 4-year follow-up, the pooled failure prevalence was 9.6% (76 of 788) for autografts and 25% (57 of 228) for allografts. The number needed to benefit to prevent 1 failure by using autografts was only 7 patients (95% CI, 5-10). Disappointing is the almost 10% failure rate even in ACL autografts in this very young, very active population, with hamstrings and patellar tendon autografts showing similar results. These results are based on very recent operative techniques and rehab protocols, with the oldest included study from 2011. Allograft surgeons are challenged in this paper because even though there was a clear difference between autografts and irradiated allografts, the difference between allograft and nonirradiated allograft was not significant. This may be a numbers problem with only a power analysis needed to determine the needed size of a subsequent study population to put the issue to rest. Consequently, it is incumbent on those using nonirradiated allografts in similar populations to demonstrate their efficacy. If you are disappointed by those failure numbers, realize that the true number of failures (excess laxity and/or pivoting) is actually worse, since 2 of the included studies used revision as the only indicator of failure. The true number of failures is likely higher because, most likely, all those that have failed have probably not come to revision yet. After ACL surgery, it is immediately necessary to focus on the rehabilitation to optimize results. Research does suggest immediately, like day 1. According to the review by Lepley,3 emphasis should be on cryotherapy, closed chain exercises, and restoration of full range of motion. Don’t bother with postoperative splints or braces, and don’t delay physical therapy for a week—start immediately. Even more helpful guidance originates from the MOON Group—don’t bother with continuous passive motion (CPM) and try to start weightbearing early to prevent patellofemoral pain.5 In the MOON cohort, postoperative bracing did not improve swelling, pain, range of motion, or safety. They suggest that open chain exercises can be started safely at 6 weeks. In an effort to maximize results respecting the mental aspect of rehabilitation, the review by Lepley3 supports “patient advice and counseling” throughout the rehabilitation process to improve self-reported outcomes. On the physical side, the exercise mode should be eccentrics all the way—especially for the quadriceps muscle. If isokinetic testing equipment is not available in your environment, you can still gauge when athletes are approaching return-to-play readiness using the limb symmetry index (LSI) of the single-leg hop for distance test.6 The distance LSI correlated well with isokinetic extension peek torque LSI but not with kinetic and kinematic symmetry 6 to 9 months postreconstruction. The study suggests that there are patients who have symmetric muscle strength with coexisting kinetic and kinematic asymmetries because of faulty neuromuscular patterns or psychological factors, meaning that they are not ready to return to play, so don’t be fooled! Movement parameters can be scrutinized by an experienced observer and improved with appropriate training. Finally, Ardern1 helps put the results of ACL injury into perspective: Returning to preinjury level of sport after ACL reconstruction is complex and multifactorial. Screening for modifiable factors, particularly the psychologic ones, may help clinicians identify those most at risk for not returning. According to Ardern,1 1 in 3 athletes does not return to his or her preinjury level, and 1 in 2 does not return to a competitive level following surgery. Fear of reinjury was an ominous factor. Clinicians, including orthopaedic surgeons, need to understand their deficiencies in recognizing these factors outside of their own clinical expertise and provide appropriate counseling while return-to-play decisions are being resolved. No doubt, more research is needed to improve the fate of the ACL-injured athlete. The studies presented in this issue of Sports Health have helped us with the task of improving the care of these athletes. Nowadays, an ACL injury does not always end an athletic career. But, we shouldn’t put all of our focus on return to play, as if that’s the endpoint of our athletic medicine responsibility. We need more answers to the problem of posttraumatic arthritis that often follows the competitive athletic career after ACL injury. Then we can safely encourage many more of these athletes to get back in the game!