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Antifungal Activity of Plumericin and Isoplumericin

descriptionPublicationkeyboard_double_arrow_right Article 01 Nov 2011 English Publisher:SAGE PublicationsJournal:Natural Product Communications, volume 6 (issn: 1934-578X, eissn: 1555-9475, Copyright policy )
Authors: Yogesh K Gupta; Dharmendra Singh; Sarman Singh; Parveen Kumar; M. P. Dobhal; Umakant Sharma;

doi: 10.1177/1934578x1100601101

pmid: 22224260

Antifungal Activity of Plumericin and Isoplumericin

Abstract

This study evaluated the in vitro antifungal activity of the chloroform extract of Plumeria bicolor and its phytoconstituents plumericin and isoplumericin against Candida species and Cryptococcus neoformans by measuring the Minimum Inhibitory Concentration (MIC) and Minimum Fungicidal Concentration (MFC). Plumericin's consistently high activity against Candida albicans, C. krusei, C. glabrata, C. tropicalis and Cryptococcus neoformans was more potent than isoplumericin and the standard antifungal drug nystatin suggesting its potential as a drug candidate for candidiasis and cryptococcosis.

Related Organizations
Keywords

Apocynaceae, Antifungal Agents, Indenes, Plant Extracts, Cryptococcus neoformans, Iridoids, Microbial Sensitivity Tests, Candida

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    citations
    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 13
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Top 10%
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 Average
    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
    		 Average
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citations
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
13
Top 10%
Average
Average
gold
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