Osteoarthritis of the knee is a degenerative condition that is commonly seen in the elderly population and sometimes occurs earlier in the athletic population. Pain and stiffness are common features, which can be debilitating. Clinical assessment of the knee joint requires consideration of its associated muscles, ligaments, tendons, bursae and menisci. The aim of this article is to provide an overview of knee pain assessment, to discuss the diagnosis of knee osteoarthritis, and to review some evidence-based management options.