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Journal of Histochemistry & Cytochemistry
Article
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Journal of Histochemistry & Cytochemistry
Article . 1969 . Peer-reviewed
License: https://journals.sagepub.com/page/policies/text-and-data-mining-license
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Journal of Histochemistry & Cytochemistry
Article . 1969
Data sources: Europe PubMed Central
https://dx.doi.org/10.1177/17....
Article
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LEAD-ADENOSINE TRIPHOSPHATE COMPLEXES IN ADENOSINE TRIPHOSPHATASE HISTOCHEMISTRY

descriptionPublicationkeyboard_double_arrow_right Article 01 Feb 1969 English Publisher:SAGE PublicationsJournal:Journal of Histochemistry & Cytochemistry, volume 17, pages 85-94 (issn: 0022-1554, eissn: 1551-5044, Copyright policy )
Authors: L W, Tice;

doi: 10.1177/17.2.85

pmid: 4237066

LEAD-ADENOSINE TRIPHOSPHATE COMPLEXES IN ADENOSINE TRIPHOSPHATASE HISTOCHEMISTRY

Abstract

Chelation of lead by adenosine triphosphate (ATP) and its consequences for adenosine triphosphatase histochemistry were examined. The formation constant of lead-ATP chelates was found by two methods to be 4.6-4.7 x 104. The characteristics of enzyme inhibition by lead were consistent with the predicted effects of lead-ATP chelation. Inhibition was overcome by increasing ATP concentrations. With the adenosine triphosphatase from liver microsomes, which retained some activity in the presence of 4 mM Pb(NO3)2, substrate inhibition disappeared and increased MgCl2 was required for optimal activity. Increased solubility of lead phosphate was observed in the presence of increasing quantities of ATP in a manner predictable from lead-ATP chelation.

Related Organizations
Keywords

Adenosine Triphosphatases, Ions, Histocytochemistry, Guinea Pigs, Hydrogen-Ion Concentration, In Vitro Techniques, Kidney, Phosphates, Rats, Kinetics, Adenosine Triphosphate, Lead, Liver, Microsomes, Animals, Calcium, Magnesium

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    selected citations
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    This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
    		 101
    popularity
    This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
    		 Average
    influence
    This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
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    impulse
    This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
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selected citations
These citations are derived from selected sources.
This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Citations provided by BIP!
popularity
This indicator reflects the "current" impact/attention (the "hype") of an article in the research community at large, based on the underlying citation network.
BIP!Popularity provided by BIP!
influence
This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).
BIP!Influence provided by BIP!
impulse
This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.
BIP!Impulse provided by BIP!
101
Average
Top 1%
Top 10%
bronze