Alteration of WWOX in human cancer, a clinical view
Copyright policy )Alteration of WWOX in human cancer, a clinical view
WWOX gene is located in FRA16D, the highly affected chromosomal fragile site. Its tumor suppressor activity has been proposed on a basis of numerous genomic alterations reported in chromosome 16q23.3–24.1 locus. WWOX is affected in many cancers, showing as high as 80% loss of heterozygosity in breast tumors. Unlike most tumor suppressors impairing of both alleles of WWOX is very rare. Despite cellular and animal models information on a WWOX role in cancer tissue is limited and sometimes confusing. This review summarizes information on WWOX in human tumors.
- Wrocław Medical University Poland
- Medical University of Lodz Poland
Male, Tumor Suppressor Proteins, Liver Neoplasms, WWOX, Loss of Heterozygosity, Prostatic Neoplasms, Breast Neoplasms, WW Domain-Containing Oxidoreductase, Neoplasms, Mutation, cancer, Humans, Female, tumor suppressor gene, Oxidoreductases, Alleles
Male, Tumor Suppressor Proteins, Liver Neoplasms, WWOX, Loss of Heterozygosity, Prostatic Neoplasms, Breast Neoplasms, WW Domain-Containing Oxidoreductase, Neoplasms, Mutation, cancer, Humans, Female, tumor suppressor gene, Oxidoreductases, Alleles
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