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Delayed Neutropenia with Ticlopidine

descriptionPublicationkeyboard_double_arrow_right Article 01 Dec 1994 English Publisher:SAGE PublicationsJournal:Annals of Pharmacotherapy, volume 28, pages 1,344-1,346 (issn: 1060-0280, eissn: 1542-6270,

Authors: Lori A. Hansen; Debra K Farver;

doi: 10.1177/106002809402801203

pmid: 7696722

Delayed Neutropenia with Ticlopidine

- Summary
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Abstract

OBJECTIVE: To report a case of ticlopidine-induced neutropenia occurring 18 days after discontinuation of the drug. CASE SUMMARY: A 68-year-old woman was placed on ticlopidine after a transient ischemic attack. Ten days later the drug was discontinued because the patient developed a rash. Eighteen days later she developed pneumonia and neutropenia, which were believed to be induced by ticlopidine. DISCUSSION: Drug-induced neutropenia is serious and at times life-threatening. Ticlopidine-induced neutropenia has been described in patients receiving the medication. We report neutropenia occurring 18 days after discontinuation of ticlopidine. CONCLUSIONS: Indications for prescribing ticlopidine must be closely followed. Complete blood cell count monitoring is imperative while the patient is receiving the medication. This case suggests that the duration of monitoring after the discontinuation of ticlopidine may need to be longer than the 14 days recommended by the manufacturer.

Related Organizations

South Dakota State University
United States

Keywords

Neutropenia, Ticlopidine, Time Factors, Ischemic Attack, Transient, Humans, Female, Pneumonia, Aged, Blood Cell Count

Impact byBIP!

	citations This is an alternative to the "Influence" indicator, which also reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	21
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	influence This indicator reflects the overall/total impact of an article in the research community at large, based on the underlying citation network (diachronically).	Top 10%
	impulse This indicator reflects the initial momentum of an article directly after its publication, based on the underlying citation network.	Average