Frequent videoconferencing usage can lead to videoconference fatigue (VF), potentially undermining students’ academic performance and mental well-being. This study aimed to adapt and validate the Chinese version of the antecedents to videoconference fatigue scale in higher education (AVFS-HE-C). Data were obtained online from 581 Chinese university students, each attending at least one videoconferencing-based course per week. Participants completed the AVFS-HE-C and provided details on their videoconferencing habits and course types. The results supported the original factor structure of the AVFS-HE, demonstrating that the Chinese adaptation is both reliable and valid. Additionally, VF was positively associated with AVFS-HE-C scores, and students enrolled in elective courses reported higher VF levels than those taking major courses. Overall, the AVFS-HE-C offers a robust instrument for measuring VF among higher education students in China.